Resolving flow and mass transport in a healthy subject-specific aorta using large eddy simulation
نویسندگان
چکیده
Background An increased level of low-density lipoprotein (LDL) has been shown to promote the accumulation of cholesterol within the intima layer of large arteries, which can be connected to the genesis of atherosclerosis. The LDL concentration on the endothelium has been found to be flow dependent, suggesting a relationship between the development of atherosclerosis and flow dynamics. In this study, we use a scale resolving turbulence model (Large eddy simulation, LES) to compute the flow and mass transfer inside a subject-specific human aorta, in order to investigate the relation between the flow and the LDL accumulation on the arterial wall.
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